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Are you looking at laboratory automation or management solutions?

Get in touch with us at [email protected]

About Us

We strongly believe that good laboratory automation is far more than just an engineering issue. The great exterior of each setup is as important to us as high throughput capacity, safety and functionality.

Hence, we put an equal amount of attention to exterior design and interior high-end technology. To create futuristic laboratory automation systems that are beautiful yet powerful, we have a talented and multi-disciplinary team of experts ranging from scientists and engineers to designers and artists. All of this is to create a unique laboratory and invite you into the world of scientific automation and mechanical art.

We design and built state-of-the-art robotic systems, artificial intelligent software and laboratory management systems used by pharmaceutical and biotech companies and academic research laboratories. We deliver high-end instruments and accessories that can be used in basic and translational research, clinical diagnostics and drug discovery, including high throughput and combinatorial screening. In particular, we develop, robotic and artificial intelligence solutions for laboratories that maximise productivity of life scientists and R&D specialists.

Our services

  •  
  • Project Management
  • Systems Implementation
  • Systems Integration
  • Instruments Delivery
  • Devices Construction
  • Facility Building
  • Assay Development
  • Automation Maintenance
  •  
Project Management

Project management is a critical component of every successful laboratory automation project.

We offer knowledge, skills, tools and techniques to project all activities to meet your requirements and encompass all aspects of the design, build and integration process.

A dedicated project manager becomes our client’s primary point of contact and project lead. We conduct an automation project kick-off, design review and wrap-up meetings, component and system timeline management, communication and coordination with relevant third parties to ensure successful implementation on time and on budget.

Systems Implementation

A lab in today’s challenging times has to be more than just paperless. It has to be more flexible and efficient than ever.

We implement instrumentation and information management systems for commercial and academic laboratories, including Laboratory Automation Scheduling (LAS), Electronic Laboratory Notebook (ELN), Laboratory Information Management System (LIMS), Sample Management System (SMS) and Facility Monitoring Systems (FMS).

As a market leader in Intelligent Laboratory Automation (ILA), we develop Gene Game™ software for evolutionary solving of multidimensional biological, biomedical and biochemical problems.

Systems Integration

Systems integration is the collecting of a number scientific instruments and generated data together and making a cohesive laboratory automation system with sample processing, instruments control and information management.

With a strong engineering and IT background, we provide a complete set of vertical, star and horizontal integration solutions within all laboratory management, facility monitoring and instrument control systems. As the part of the integration process we build the required accessories, supply lines and installations for robots and instrumentation.

Instruments Delivery

Robots, liquid handling, plate readers, high content analysers, automatic incubators, plate stackers and other robotic lab equipment are crucial part of each automation facility.

Choosing the proper instrument is not trivial. We carefully test and compare the quality, compatibility and efficiency of the instruments available on the market to ensure we recommend our clients the best option for their needs and their budget. Thanks to obtained discounts from major instruments vendors and a large inventory of high quality pre-owned laboratory equipment, we offer new and refurbished automatics at unbeatable prices.

Device Construction

We manufacture a customised line of devices and components to perform a series of laboratory robotic plate manipulation tasks for a biological sample preparation or experimentation process. These accessories complement our other products, providing a number of operations such as sample freezing, plate storage, tip cleaning and instrument positioning allowing us to deliver total laboratory automation solutions based on individual needs.

Facility Building

Apart from bench-top-sized automation, we specialise in larger cells based on central six-axis robots used to perform a series of laboratory robotic plate manipulation tasks on numerous instruments and accessories. These integrated work cells need more space, and therefore we build dedicated facilities. Usually, our facilities are air-conditioned, clean rooms that maintain sterility for cell-based assays with electricity, network, laboratory vacuum, compressed air, gaseous nitrogen and carbon dioxide installations. They are controlled by a Facility Monitoring System (FMS) via the operator panel and ultra-high definition monitors.

Assay Development

With expertise in cancer biology, protein chemistry, immunology and molecular biology, we offer a range of custom development services including bioassays for drug discovery, basic research and process validation. Our services span from assay development and adaptation, for hit finding and profiling purposes, to compound selection, selectivity testing, combinatorial and high capacity screening and hit characterisation.

Automation Maintenance

At Labomatica, we understand that warranty and support is the calling card of each company. So, we deliver what we promise – uncompromising client service and a commitment to excellence. We troubleshoot, repair and maintain management laboratory systems and automation cells, including robots and accessories, electromechanical installations, programmable logic controls, conveyors lines and pneumatic systems.

Systems

See technologies

we can provide

Intelligent Laboratory Automation (ILA)

Intelligent Laboratory Automation (ILA)

An Intelligent Laboratory System (ILA) is an artificial intelligence system that solves the major limitations of the existing High Throughput Screening (HTS) centres, concerning their linear mode of action, i.e. the results collected during a single set of experiments require human analysis and reasoning before the next set of experiments can be performed. The main idea of an Intelligent Screening System is going towards the concepts introduced by futurologists of the 20th century of Total Laboratory Automation (TLA) or Automatic Drug Factory (ADF). In simple terms, via integration with automation scheduler, Intelligent Laboratory Automation establishes closed-loop machinery that is able to work in an iterative mode for automatic and efficient solving of multidimensional biological problems without human intervention.

Laboratory Automation Scheduling (LAS)

Laboratory Automation Scheduling (LAS)

A Laboratory Automation Scheduling (LAS) is a system for driving the integration of laboratory automation throughout sample preparation and experiment processing. This system lets operators define, execute and monitor a broad range of processes and workflows in an intuitive graphical interface. With the Laboratory Automation Scheduling, diverse devices such as robots, incubators, liquid stations, plate readers and high-content workstations can be tightly integrated towards maximum throughput and optimal resource utilization. The open topology architecture allows the operator to specify instrumentation, lab ware and operation to support a broad range of processes and workflows.

Electronic Laboratory Notebook (ELN)

Electronic Laboratory Notebook (ELN)

An Electronic Laboratory Notebook (ELN) is a paperless lab archive for cross-team collaboration. An ELN ensures procedural execution, automates manual processes and collects instruments data to simplify and accelerate the R&D process and streamlines data management. ELNs are considered legal documents and may be entered as evidence in a court of law, often in association with intellectual property litigation.

Laboratory Information Management System (LIMS)

Laboratory Information Management System (LIMS)

A Laboratory Information Management System (LIMS) is a central management system that supports a modern laboratory's operations. Key features include — but are not limited to — workflow and data tracking support, flexible architecture and data exchange interfaces, which fully "support its use in regulated environments." By using an LIMS, laboratories automate workflows, integrate instruments and manage samples and associated information to improve productivity.

Sample Management System (SMS)

Sample Management System (SMS)

A Sample Management is a part of laboratory workflow — one of the essentials of a management system. Proper management of samples is critical to the accuracy and reliability of chemical and biological analysis. Keeping track of laboratory samples information – properties, location, dates, status, expiration and more – is absolutely necessary for high throughout labs working on tens of thousands of compounds.

Facility Monitoring System (FMS)

Facility Monitoring System (FMS)

A Facility Monitoring System is a monitoring software suite that collects data from sensors in real-time and provides operational personnel with information on the performance of the clean room. The system documents physical and microbiological parameters to meet Good Laboratory Practise (GLP) and the legislation requirements for drug development. Standard inputs include particles, door contacts, temperature, relative humidity, differential pressures and air velocity. Software presents that data as graphic information and notifies facility operators of alert limits to enable an immediate response to an unwanted event or excursion.

SOFTWARE

Our own, clever and effective software solution

Gene Game
Overview
Gene Game™ is our flagship intelligent software for the automatic solving of multidimensional biological, biomedical and biochemical problems.
Through integration with the scheduling system, lab high capacity instrumentation and relative databases Gene Game™ automates sample preparation, experiment processing and results reasoning in a closed-loop manner. It means that the results collected during a single set of high throughput experiments do not require human analysis, and next, the set of experiments can be planned and performed automatically. Thanks to an intelligent approach, this iterative circular process is much more effective than the human mind in finding solutions in a multidimensional search space.
Artificial intelligence core of Gene Game™ is based on genetic algorithms (GA) that generate high-quality solutions to optimisation and search problems by relying on the bio-inspired process of natural selection. The algorithms repeatedly modify a population of individual probes. At each set of experiments, on the basis of the obtained results, the genetic algorithms select the most promising probes and rearrange their formulas by crossing together and by introducing random changes. Over successive experiments, the population of probes "evolves" toward an optimal solution.
Gene Game™ may be the heart of the Intelligent Laboratory Automation (ILA), Total Laboratory Automation (TLA) or Automatic Drug Factory (ADF) systems. This innovative software implements our vision of futuristic laboratory without humans in which AI robots conduct high throughput experiments and make evolutionary-driven discoveries.
Features
Interface
  • Cross-platform browser support (Windows, Linux, MacOS)
Algorithms
  • Conducting up to 10 evolutionary processes up to 100 000 generations each
  • Encoding of at least 100 parameters at 100 levels in a sequence of appropriate length
  • Encoding of chromosomes in a binary system and using floating-point numbers
  • Generation of a population with at least 10 000 000 individuals
  • Defining genetic operations (two-point and multi-point crossover, mutation and inversion)
  • Adaptive function scaling (linear scaling, sigma truncation and power law scaling)
  • Various selection methods (roulette wheel selection, rank selection, threshold selection and crowding selection)
  • Random selection of the initial population with an option to define genotypes manually
Functionality
  • Visualisation of evolutionary process and exporting charts in PNG, JPEG, TIFF and PDF formats
  • Generation of statistics for each generation with a preview of historical data
  • Manual chromosome editing and adaptive value settings
  • Saving of selected populations and generations of the evolutionary process
  • Opening a population file and continuing the population evolution
  • Mathematical formula editor for defining adaptive functions
Data import and export
  • Importing individual adaptation data from readers and high content imagers (Biotek Cytation, BMG Pherastar, Perkin Elmer Envision, Perkin Elmer Opera Phenix, Molecular Devices ImageXpress)
  • Importing individuals ID using a barcode reader (Agilent Barcode Reader, Generic Barcode Reader, RVSI VR4000)
  • Exporting a solution recipe for every individual to a liquid handling station (Tecan Evo, Agilent Bravo, Hamilton Vantage/Star/Nimbus, Becman Coulter Biomek, Formulatrix Tempest, Perkin Elmer Janus, Labcyte Echo 500 series)
  • Exporting identification data of individuals for a plate labeller (Agilent Microplate Labeller)
Applications
  • Combinatorial screening of chemical compounds repositories for their selectivity on the chosen metabolic pathways;
  • Chemosensitivity tests on patients' individual cancer cells for finding individualised cocktails of anti-cancer drugs for their personal anti-cancer therapies;
  • Modelling disease from omic data for its better diagnosis, prognosis and treatment;
  • Optimisation of stem cell media towards their differentiation potency into various types of cells;
  • Finding buffers and chemical solutions for efficient crystallization of biological proteins and peptides;
  • Optimization of bioprocesses and biotechnologies, e.g. production of therapeutic mononoclonal antibodies or chemotherapeutic agents in bioreactors;
  • Finding optimal content of buffers and physical factors for optimal reactivity of recombinant enzymes;
  • Searching monoclonal antibody libraries for chosen antigens;
  • Modelling evolution processes for a better understanding and verification of evolution theories, concepts and hypotheses;
  • Determining tertiary and quaternary structures of macromolecules, such as proteins and nucleic acids.

Instruments

Instruments
We offer a wide range of robotic instrumentation to support the entire range of protocols commonly encountered in HTS laboratories from high-throughput sample preparation through vast, multi-component analysis systems to support an entire experimental effort.

Here are some examples:

6-AXIS ROBOTS
  • Mitsubishi RV-2F
  • Mitsubishi RV-4F
  • Mitsubishi RV-4FL
  • Mitsubishi RV-7F
  • Mitsubishi RV-7FL
  • Mitsubishi RV-7FLLM
BARCODE LABELLERS
  • Agilent Microplate Barcode Labeller
Barcode Readers
  • Agilent Barcode Reader
Centrifuge
  • Agilent Microplate Centrifuge
Liquid Handlers
  • Agilent Bravo Automated Liquid Handling Platform
  • Agilent Vertical Pipetting Station
Microplate Handlers
  • Agilent BenchCel Microplate Handling Workstation
  • Agilent BioCel 900, 1200 and 1800 Systems
Microplate Storage
  • Agilent Labware Stacker
  • Agilent Plate Hub Carousel
  • Thermo Cytomat 2 Series Incubators
  • Thermo Heraeus Cytomat 600x Series Incubators
  • Thermo Cytomat 44-D Incubator
Microplate Washers
  • BioTek ELx 405 HT
  • BioTek ELx 405 Select
  • BioTek ELx 405 Magna
  • BioTek Washer ELx 406
Readers and Imagers
  • BMG LabSystems RubyStar
  • BMG Lab Systems PheraStar
  • BioTek Synergy 4
Sealers, Peelers & Piercers
  • Agilent PlateLoc Thermal Microplate Sealer
  • Agilent Microplate Seal Piercer
  • Nexus Biosystems Xpeel
Applications

Automation is

a key technology...

...for a variety of laboratories with complex protocols that must be executed efficiently and accurately on large numbers of samples. Our robotic and management systems offer high throughput sample preparation and rapid analysis for a wide range of bioscience applications:
  • ADME/Tox
  • Apoptosis Assays
  • Biobanking
  • Bioprocess Optimisation
  • Cell Culture
  • Cell Separation
  • Cell-based Assays
  • Cellular Imaging
  • Colony Picking
  • Colony Plating
  • Combinatorial Screening
  • Compound Delivery
  • Compound Solubilisation
  • Compound Storage
  • DNA Extraction
  • DNA Normalization
  • Dynamic Light Scattering
  • ELISA Assays
  • Flow Cytometry
  • Gene Assembly
  • Gene Construction
  • High Content Screening
  • High Throughput Screening
  • Kinetic Assays
  • Label-Free Assays
  • Mass Spec Screening
  • Multiplexing Assays
  • Next-Gen Sequencing
  • Normalization
  • Oligo Deprotection
  • Combinatorial Screening
  • Compound Delivery
  • Compound Solubilisation
  • Compound Storage
  • DNA Extraction
  • DNA Normalization
  • Dynamic Light Scattering
  • ELISA Assays
  • Flow Cytometry
  • Gene Assembly
  • Gene Construction
  • High Content Screening
  • High Throughput Screening
  • Kinetic Assays
  • Label-Free Assays
  • Mass Spec Screening
  • Multiplexing Assays
  • Next-Gen Sequencing
  • Normalization
  • Oligo Deprotection